The effects of adrenocortical steroids on the redness and hemorrhage at the operation wound after pacemaker implantation.

This study was performed to investigate the effects of adrenocorticoid steroids, Prednisolone sodium hemisuccinate, Dexamethasone, and Betamethasone disodium phosphate, on the wound healing of permanent pacemaker implantation, especially on the :findings of redness and local hemorrhage. It was found that prednisolone sodium hemisuccinate and betamethasone disodium phosphate had a remarkable prophylactic effect on the redness along the operation wound and, moreover, on the hemorrhage from the wound, but dexamethasone had not any prophylactic effect on the redness and hemorrhage along the wound. It might be, therefore, said that the mode of action of adrenocortical steroids on the redness and inflammatory reaction along the wound or the pharmacological efficiency differed by those chemical compounds. 9